Structure based design, synthesis and activity studies of small hybrid molecules as HDAC and G9a dual inhibitors

Aberrant enzymatic activities or expression profiles of epigenetic regulations are therapeutic targets for cancers. Among these, histone 3 lysine 9 methylation (H3K9Me2) and global de-acetylation on histone proteins are associated with multiple cancer phenotypes including leukemia, prostatic carcino...

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Detalles Bibliográficos
Autores principales: Zang, Lanlan, Kondengaden, Shukkoor M., Zhang, Qing, Li, Xiaobo, Sigalapalli, Dilep K., Kondengadan, Shameer M., Huang, Kenneth, Li, Keqin Kathy, Li, Shanshan, Xiao, Zhongying, Wen, Liuqing, Zhu, Hailiang, Babu, Bathini N., Wang, Lijuan, Che, Fengyuan, Wang, Peng George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609913/
https://www.ncbi.nlm.nih.gov/pubmed/28968981
http://dx.doi.org/10.18632/oncotarget.18730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609913/
https://www.ncbi.nlm.nih.gov/pubmed/28968981
http://dx.doi.org/10.18632/oncotarget.18730

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