Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells

Tripchlorolide (T4) has been shown to induce A549 lung cancer cell death predominantly by activating an autophagy pathway. However, the underlying mechanism remains unclear. Herein, we demonstrated that compared with T4 treatment alone, pretreatment with wortmannin (an inhibitor of phosphatidylinosi...

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Detalles Bibliográficos
Autores principales: Chen, Li-Min, Song, Tian-Jiao, Xiao, Jian-Hong, Huang, Zheng-Hui, Li, Yong, Lin, Ting-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609972/
https://www.ncbi.nlm.nih.gov/pubmed/28969040
http://dx.doi.org/10.18632/oncotarget.19201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609972/
https://www.ncbi.nlm.nih.gov/pubmed/28969040
http://dx.doi.org/10.18632/oncotarget.19201

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