USP21 regulates Hippo pathway activity by mediating MARK protein turnover

The Hippo pathway, which acts to repress the activity of YAP and TAZ trancriptional co-activators, serve as a barrier for oncogenic transformation. Unlike other oncoproteins, YAP and TAZ are rarely activated by mutations or amplified in cancer. However, elevated YAP/TAZ activity is frequently observ...

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Detalles Bibliográficos
Autores principales: Nguyen, Hung Thanh, Kugler, Jan-Michael, Loya, Anand C., Cohen, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609986/
https://www.ncbi.nlm.nih.gov/pubmed/28969054
http://dx.doi.org/10.18632/oncotarget.19322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609986/
https://www.ncbi.nlm.nih.gov/pubmed/28969054
http://dx.doi.org/10.18632/oncotarget.19322

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