BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands

Using syngeneic BALB/c mouse breast cancer models, we show that the chromatin remodeling subunit bromodomain PHD finger transcription factor (BPTF) suppresses natural killer (NK) cell antitumor activity in the tumor microenvironment (TME). In culture, BPTF suppresses direct natural cytotoxicity rece...

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Detalles Bibliográficos
Autores principales: Mayes, Kimberly, Elsayed, Zeinab, Alhazmi, Aiman, Waters, Michael, Alkhatib, Suehyb G., Roberts, Mark, Song, Carolyn, Peterson, Kristen, Chan, Vivian, Ailaney, Nikhil, Malapati, Pumoli, Blevins, Tana, Lisnić, Berislav, Dumur, Catherine I., Landry, Joseph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610007/
https://www.ncbi.nlm.nih.gov/pubmed/28969075
http://dx.doi.org/10.18632/oncotarget.17834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610007/
https://www.ncbi.nlm.nih.gov/pubmed/28969075
http://dx.doi.org/10.18632/oncotarget.17834

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