In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting

Precise genome editing involves homologous recombination between donor DNA and chromosomal sequences subjected to double-stranded DNA breaks made by programmable nucleases. Ideally, genome editing should be efficient, specific, and accurate. However, besides constituting potential translocation-init...

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Detalles Bibliográficos
Autores principales: Chen, Xiaoyu, Janssen, Josephine M., Liu, Jin, Maggio, Ignazio, ‘t Jong, Anke E. J., Mikkers, Harald M.M., Gonçalves, Manuel A. F. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610252/
https://www.ncbi.nlm.nih.gov/pubmed/28939824
http://dx.doi.org/10.1038/s41467-017-00687-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610252/
https://www.ncbi.nlm.nih.gov/pubmed/28939824
http://dx.doi.org/10.1038/s41467-017-00687-1

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