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In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting

Precise genome editing involves homologous recombination between donor DNA and chromosomal sequences subjected to double-stranded DNA breaks made by programmable nucleases. Ideally, genome editing should be efficient, specific, and accurate. However, besides constituting potential translocation-init...

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Detalles Bibliográficos
Autores principales:	Chen, Xiaoyu, Janssen, Josephine M., Liu, Jin, Maggio, Ignazio, ‘t Jong, Anke E. J., Mikkers, Harald M.M., Gonçalves, Manuel A. F. V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610252/ https://www.ncbi.nlm.nih.gov/pubmed/28939824 http://dx.doi.org/10.1038/s41467-017-00687-1

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