Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae

Kynurenic acid (KA) is a tryptophan (Trp) metabolite that is synthesised in a branch of kynurenine (KYN) pathway. KYN aminotransferase (KAT) catalyses deamination of KYN, yielding KA. Although KA synthesis is evolutionarily conserved from bacteria to humans, the cellular benefits of synthesising KA...

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Detalles Bibliográficos
Autores principales: Ohashi, Kazuto, Chaleckis, Romanas, Takaine, Masak, Wheelock, Craig E., Yoshida, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610271/
https://www.ncbi.nlm.nih.gov/pubmed/28939805
http://dx.doi.org/10.1038/s41598-017-12392-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610271/
https://www.ncbi.nlm.nih.gov/pubmed/28939805
http://dx.doi.org/10.1038/s41598-017-12392-6

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