Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies

Bitter taste receptors (TAS2Rs) have attracted a great deal of interest because of their recently described bronchodilator and anti-inflammatory properties. The aim of this study was to identify natural direct TAS2R14 agonists from Radix Bupleuri that can inhibit mast cell degranulation. A ligand-ba...

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Detalles Bibliográficos
Autores principales: Zhang, Yuxin, Wang, Xing, Li, Xi, Peng, Sha, Wang, Shifeng, Huang, Christopher Z., Huang, Corine Z., Zhang, Qiao, Li, Dai, Jiang, Jun, Ouyang, Qin, Zhang, Yanling, Li, Shiyou, Qiao, Yanjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610306/
https://www.ncbi.nlm.nih.gov/pubmed/28939897
http://dx.doi.org/10.1038/s41598-017-11720-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610306/
https://www.ncbi.nlm.nih.gov/pubmed/28939897
http://dx.doi.org/10.1038/s41598-017-11720-0

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