Cargando…

Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies

Bitter taste receptors (TAS2Rs) have attracted a great deal of interest because of their recently described bronchodilator and anti-inflammatory properties. The aim of this study was to identify natural direct TAS2R14 agonists from Radix Bupleuri that can inhibit mast cell degranulation. A ligand-ba...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yuxin, Wang, Xing, Li, Xi, Peng, Sha, Wang, Shifeng, Huang, Christopher Z., Huang, Corine Z., Zhang, Qiao, Li, Dai, Jiang, Jun, Ouyang, Qin, Zhang, Yanling, Li, Shiyou, Qiao, Yanjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610306/ https://www.ncbi.nlm.nih.gov/pubmed/28939897 http://dx.doi.org/10.1038/s41598-017-11720-0

Ejemplares similares

Identification of Natural Compound Carnosol as a Novel TRPA1 Receptor Agonist
por: Zhai, Chenxi, et al.
Publicado: (2014)

Clerosterol from vinegar-baked radix bupleuri modifies drug transport
por: Zhao, Ya, et al.
Publicado: (2017)

Phylogenetic relationship and comparative analysis of the main Bupleuri Radix species in China
por: Wang, Ping, et al.
Publicado: (2023)

A Network Pharmacology Study on the Active Components and Targets of the Radix Ginseng and Radix Bupleuri Herb Pair for Treating Nonalcoholic Fatty Liver Disease
por: Zhang, Qiang, et al.
Publicado: (2022)

Salvianolic Acid A, as a Novel ETA Receptor Antagonist, Shows Inhibitory Effects on Tumor in Vitro
por: Zhang, Qiao, et al.
Publicado: (2016)

Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats
por: Tian, Dan-Dan, et al.
Publicado: (2016)

Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain
por: Wang, Shifeng, et al.
Publicado: (2016)

Ultrasensitive Time-Resolved Fluoroimmunoassay for Saikosaponin a in Chaihu (Bupleuri Radix)
por: Chao, Zhi, et al.
Publicado: (2016)

Investigation on ultrasound assisted extraction of saikosaponins from Radix Bupleuri
por: Zhao, Shuna, et al.
Publicado: (2007)

Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer’s disease
por: Li, Juan, et al.
Publicado: (2022)

Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses
por: Shen, Xia, et al.
Publicado: (2017)

Systematic transcriptome analysis reveals molecular mechanisms and indications of bupleuri radix
por: Park, Sang-Min, et al.
Publicado: (2022)

Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology
por: Yang, Fude, et al.
Publicado: (2017)

A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications
por: Yuan, Bochuan, et al.
Publicado: (2016)

Identification of the original plants of cultivated Bupleuri Radix based on DNA barcoding and chloroplast genome analysis
por: Zhang, Gaixia, et al.
Publicado: (2022)

Mouse Single Oral Dose Toxicity Test of Bupleuri Radix Aqueous Extracts
por: Kim, Kyung-Hu, et al.
Publicado: (2012)

Simultaneous Extraction and Analysis of Seven Major Saikosaponins from Bupleuri Radix and the Exploration of Antioxidant Activity and Its Mechanism
por: Wang, Ning, et al.
Publicado: (2023)

Multielements determination and metal transfer investigation in herb medicine Bupleuri Radix by inductively coupled plasma‐mass spectrometry
por: Li, Kunlun, et al.
Publicado: (2018)

Synergistic Effect of Bupleuri Radix and Scutellariae Radix on Adipogenesis and AMP-Activated Protein Kinase: A Network Pharmacological Approach
por: Lee, Jueun, et al.
Publicado: (2018)

Bupleuri radix for Acute Uncomplicated Respiratory Tract Infection: A Systematic Review of Randomized Controlled Trials
por: Yan, Li-Jiao, et al.
Publicado: (2022)

Vinegar amount in the process affected the components of vinegar-baked Radix Bupleuri and its hepatoprotective effect
por: Zhao, Ya, et al.
Publicado: (2016)

Dose-Effect/Toxicity of Bupleuri Radix on Chronic Unpredictable Mild Stress and Normal Rats Based on Liver Metabolomics
por: Wang, Peng, et al.
Publicado: (2021)

Network pharmacology and molecular docking technology for exploring the effect and mechanism of Radix Bupleuri and Radix Paeoniae Alba herb-pair on anti-hepatitis: A review
por: Huang, Long, et al.
Publicado: (2023)

Network-based pharmacology and molecular docking exploring the “Bupleuri Radix-Scutellariae Radix” mechanism of action in the viral hepatitis B treatment
por: Long, Piao, et al.
Publicado: (2022)

Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase
por: Chen, Congcong, et al.
Publicado: (2023)

Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms
por: Li, Xi, et al.
Publicado: (2019)

Vinegar-baked Radix Bupleuri modulates the cell membrane constituents and inhibits the P-gp activity in rat hepatocytes
por: Zhao, Ruizhi, et al.
Publicado: (2014)

Comparative Study on Anti-Inflammatory Effect of Polysaccharides from Vinegar-Baked Radix Bupleuri Using Different Methods
por: Wei, Ni, et al.
Publicado: (2023)

Comparison of Volatile Components between Raw and Vinegar Baked Radix Bupleuri by GC-MS Based Metabolic Fingerprinting Approach
por: Xing, Jie, et al.
Publicado: (2015)

Comparative Effect of Aqueous and Methanolic Bupleuri Radix Extracts on Hepatic Uptake of High-Density Lipoprotein and Identification of the Potential Target in HFD-Fed Mice
por: Tan, Zhibin, et al.
Publicado: (2019)

Antioxidant and Proliferative Activities of Bupleuri Radix Extract Against Serum Deprivation in SH-SY5Y Cells
por: Seo, Mi Kyoung, et al.
Publicado: (2013)

Rosmarinic Acid as a Candidate in a Phenotypic Profiling Cardio-/Cytotoxicity Cell Model Induced by Doxorubicin
por: Zhang, Qiao, et al.
Publicado: (2020)

Bupleuri Radix Prevents the Recurrences of Resected Colonic Polyps by Affecting Angiogenin-2-Induced Protein Kinase B/Akt Signaling
por: Gao, Qiang, et al.
Publicado: (2020)

Studies on the Changes of Pharmacokinetics Behaviors of Phytochemicals and the Influence on Endogenous Metabolites After the Combination of Radix Bupleuri and Radix Paeoniae Alba Based on Multi-Component Pharmacokinetics and Metabolomics
por: Chen, Congcong, et al.
Publicado: (2021)

Risk of Liver Injury Associated with Chinese Herbal Products Containing Radix bupleuri in 639,779 Patients with Hepatitis B Virus Infection
por: Lee, Chang-Hsing, et al.
Publicado: (2011)

The complete chloroplast genome of Bupleurum marginatum var. stenophyllum (H. Wolff) Shan & Yin Li (Apiaceae), a new substitution for Chinese medicinal material, Bupleuri Radix (Chai hu)
por: Zhang, Gaixia, et al.
Publicado: (2021)

Deciphering the Differential Effective and Toxic Responses of Bupleuri Radix following the Induction of Chronic Unpredictable Mild Stress and in Healthy Rats Based on Serum Metabolic Profiles
por: Gao, Xiaoxia, et al.
Publicado: (2018)

Quantitative Analysis and Differential Evaluation of Radix Bupleuri Cultivated in Different Regions Based on HPLC-MS and GC-MS Combined with Multivariate Statistical Analysis
por: Wang, Zhenhuan, et al.
Publicado: (2022)

A Discovery Strategy for Active Compounds of Chinese Medicine Based on the Prediction Model of Compound-Disease Relationship
por: Huo, Mengqi, et al.
Publicado: (2022)

Anti-Inflammatory Effects of Aurantio-Obtusin from Seed of Cassia obtusifolia L. through Modulation of the NF-κB Pathway
por: Hou, Jingyi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_le04rn1joc1vht5cs9uglqt5p0