Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells

Increased availability of homeostatic cytokines is considered a major mechanism by which lymphodepletion enhances the efficacy of adoptive T cell therapy (ACT). IL-7 is one such cytokine capable of augmenting the function of tumor-reactive CD8+ T cells. However, whether host-derived IL-7 plays a rol...

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Detalles Bibliográficos
Autores principales: Ding, Zhi-Chun, Habtetsion, Tsadik, Cao, Yang, Li, Tao, Liu, Chufeng, Kuczma, Michal, Chen, Tingting, Hao, Zhonglin, Bryan, Locke, Munn, David H., Zhou, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610351/
https://www.ncbi.nlm.nih.gov/pubmed/28939858
http://dx.doi.org/10.1038/s41598-017-12488-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610351/
https://www.ncbi.nlm.nih.gov/pubmed/28939858
http://dx.doi.org/10.1038/s41598-017-12488-z

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