A Comparative QSAR Analysis, Molecular Docking and PLIF Studies of Some N-arylphenyl-2, 2-Dichloroacetamide Analogues as Anticancer Agents

Dichloroacetate (DCA) is a simple and small anticancer drug that arouses the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA can selectively promote mitochondria-regulated apoptosis, depolarizing the hyperpolarized inn...

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Detalles Bibliográficos
Autores principales: Fereidoonnezhad, Masood, Faghih, Zeinab, Mojaddami, Ayyub, Rezaei, Zahra, Sakhteman, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610753/
https://www.ncbi.nlm.nih.gov/pubmed/29535790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610753/
https://www.ncbi.nlm.nih.gov/pubmed/29535790

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