Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME Testing

Cytochrome 2B6 (CYP2B6) has substantial clinical effects on morbidity and mortality and its effects on drug metabolism should be part of hepatotoxicity screening. Examples of CYP2B6's impacts include its linkage to mortality during cyclophosphamide therapy and its role in determining hepatotoxi...

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Detalles Bibliográficos
Autores principales: Hammond, Timothy G., Birdsall, Holly H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610861/
https://www.ncbi.nlm.nih.gov/pubmed/29081796
http://dx.doi.org/10.1155/2017/1907952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610861/
https://www.ncbi.nlm.nih.gov/pubmed/29081796
http://dx.doi.org/10.1155/2017/1907952

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