Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPP(swe) Mice Without Inducing Microhemorrhage

Verubecestat is a potent BACE1 enzyme inhibitor currently being investigated in Phase III trials for the treatment of mild-to-moderate and prodromal Alzheimer’s disease. Multiple anti-amyloid immunotherapies have been dose-limited by adverse amyloid related imaging abnormalities such as vasogenic ed...

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Detalles Bibliográficos
Autores principales: Villarreal, Stephanie, Zhao, Fuqiang, Hyde, Lynn A., Holder, Daniel, Forest, Thomas, Sondey, Marie, Chen, Xia, Sur, Cyrille, Parker, Eric M., Kennedy, Matthew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611839/
https://www.ncbi.nlm.nih.gov/pubmed/28800329
http://dx.doi.org/10.3233/JAD-170056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611839/
https://www.ncbi.nlm.nih.gov/pubmed/28800329
http://dx.doi.org/10.3233/JAD-170056

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