Cargando…

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPP(swe) Mice Without Inducing Microhemorrhage

Verubecestat is a potent BACE1 enzyme inhibitor currently being investigated in Phase III trials for the treatment of mild-to-moderate and prodromal Alzheimer’s disease. Multiple anti-amyloid immunotherapies have been dose-limited by adverse amyloid related imaging abnormalities such as vasogenic ed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villarreal, Stephanie, Zhao, Fuqiang, Hyde, Lynn A., Holder, Daniel, Forest, Thomas, Sondey, Marie, Chen, Xia, Sur, Cyrille, Parker, Eric M., Kennedy, Matthew E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611839/ https://www.ncbi.nlm.nih.gov/pubmed/28800329 http://dx.doi.org/10.3233/JAD-170056

Ejemplares similares

Mannan-Abeta(28 )conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
por: Petrushina, Irina, et al.
Publicado: (2008)

Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice
por: Honarpisheh, Pedram, et al.
Publicado: (2020)

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain
por: Heiland, Tina, et al.
Publicado: (2018)

A Novel Form of Compensation in the Tg2576 Amyloid Mouse Model of Alzheimer’s Disease
por: Somogyi, Attila, et al.
Publicado: (2016)

Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes
por: Baldassarro, Vito Antonio, et al.
Publicado: (2017)

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
por: Rogers, Kathryn, et al.
Publicado: (2012)

Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology
por: Kam, Korey, et al.
Publicado: (2016)

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
por: Lilja, Anna M., et al.
Publicado: (2013)

Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease
por: Porcellotti, Sara, et al.
Publicado: (2015)

Age-related changes of protein SUMOylation balance in the AβPP Tg2576 mouse model of Alzheimer's disease
por: Nisticò, Robert, et al.
Publicado: (2014)

Effect of genotype and age on cerebral [(18)F]FDG uptake varies between transgenic APP(Swe)-PS1(dE9) and Tg2576 mouse models of Alzheimer’s disease
por: Snellman, Anniina, et al.
Publicado: (2019)

Correction: Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
por: Lilja, Anna M., et al.
Publicado: (2013)

Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy
por: van Veluw, Susanne J., et al.
Publicado: (2016)

Leaky Ryanodine receptors increases Amyloid-beta load and induces memory impairments in Tg2576 mouse model of Alzheimer disease
por: Oulès, Bénédicte, et al.
Publicado: (2013)

Up-regulation of Synaptotagmin IV within amyloid plaque-associated dystrophic neurons in Tg2576 mouse model of Alzheimer’s disease
por: Tratnjek, Larisa, et al.
Publicado: (2013)

Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer’s disease
por: Boonruamkaew, Phetcharat, et al.
Publicado: (2017)

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease
por: Evans, Charles E., et al.
Publicado: (2020)

Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer’s model
por: Hanafy, Amira Sayed, et al.
Publicado: (2023)

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease
por: Portbury, Stuart D., et al.
Publicado: (2017)

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid
por: Nichol, Kathryn E, et al.
Publicado: (2008)

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
por: Martín-Moreno, Ana María, et al.
Publicado: (2012)

Amyloid β-Induced Upregulation of Na(v)1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer’s Disease Mouse Model
por: Ciccone, Roselia, et al.
Publicado: (2019)

Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease
por: Joseph-Mathurin, Nelly, et al.
Publicado: (2021)

Neuritin Attenuates Cognitive Function Impairments in Tg2576 Mouse Model of Alzheimer's Disease
por: Choi, Yoori, et al.
Publicado: (2014)

Dysbiosis of Fecal Microbiota in Tg2576 Mice for Alzheimer’s Disease during Pathological Constipation
por: Kim, Ji-Eun, et al.
Publicado: (2022)

Amyloid Beta Pathology Exacerbates Weight Loss and Brain Cytokine Responses following Low-Dose Lipopolysaccharide in Aged Female Tg2576 Mice
por: Knopp, Rachel C., et al.
Publicado: (2022)

Prophylactic evaluation of verubecestat on disease‐ and symptom‐modifying effects in 5XFAD mice
por: Oblak, Adrian L., et al.
Publicado: (2022)

Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice
por: Hurko, Orest, et al.
Publicado: (2010)

Iron Chelation Inhibits Osteoclastic Differentiation In Vitro and in Tg2576 Mouse Model of Alzheimer’s Disease
por: Guo, Jun-Peng, et al.
Publicado: (2015)

Decreased Myelinated Fibers in the Hippocampal Dentate Gyrus of the Tg2576 Mouse Model of Alzheimer’s Disease
por: Lu, Wei, et al.
Publicado: (2016)

Quantitative study of the capillaries within the white matter of the Tg2576 mouse model of Alzheimer's disease
por: Zhang, Yi, et al.
Publicado: (2019)

Paraoxonase-1 and -3 Protein Expression in the Brain of the Tg2576 Mouse Model of Alzheimer’s Disease
por: Salazar, Jose Gregorio, et al.
Publicado: (2021)

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
por: Kaya, Ibrahim, et al.
Publicado: (2016)

Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy
por: Das, Pritam, et al.
Publicado: (2006)

In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice
por: Morales-Corraliza, Jose, et al.
Publicado: (2009)

Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease
por: Thomas, Riya, et al.
Publicado: (2020)

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice
por: Wolf, Andrea, et al.
Publicado: (2016)

Environmental enrichment does not influence hypersynchronous network activity in the Tg2576 mouse model of Alzheimer’s disease
por: Bezzina, Charlotte, et al.
Publicado: (2015)

Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease
por: Krezymon, Alice, et al.
Publicado: (2013)

Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice
por: Lee, Yu-Young, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ob7b5cn8iepmbvpohkulchu0vq