Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells

Intestinal epithelial stem cells (IESCs) are critical to maintain intestinal epithelial function and homeostasis. We tested the hypothesis that aging promotes IESC dysfunction using old (18-22 months) and young (2-4 month) Sox9-EGFP IESC reporter mice. Different levels of Sox9-EGFP permit analyses o...

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Detalles Bibliográficos
Autores principales: Moorefield, Emily C., Andres, Sarah F., Blue, R. Eric, Van Landeghem, Laurianne, Mah, Amanda T., Santoro, M. Agostina, Ding, Shengli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611984/
https://www.ncbi.nlm.nih.gov/pubmed/28854151
http://dx.doi.org/10.18632/aging.101279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611984/
https://www.ncbi.nlm.nih.gov/pubmed/28854151
http://dx.doi.org/10.18632/aging.101279

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