Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy

The 2 main degradative pathways that contribute to proteostasis are the ubiquitin-proteasome system and autophagy but how they are molecularly coordinated is not well understood. Here, we demonstrate an essential role for an effector caspase in the activation of compensatory autophagy when proteasom...

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Detalles Bibliográficos
Autores principales: Choutka, Courtney, DeVorkin, Lindsay, Go, Nancy Erro, Hou, Ying-Chen Claire, Moradian, Annie, Morin, Gregg B., Gorski, Sharon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Basic Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612217/
https://www.ncbi.nlm.nih.gov/pubmed/28806103
http://dx.doi.org/10.1080/15548627.2017.1339004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612217/
https://www.ncbi.nlm.nih.gov/pubmed/28806103
http://dx.doi.org/10.1080/15548627.2017.1339004

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