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Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy
The 2 main degradative pathways that contribute to proteostasis are the ubiquitin-proteasome system and autophagy but how they are molecularly coordinated is not well understood. Here, we demonstrate an essential role for an effector caspase in the activation of compensatory autophagy when proteasom...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612217/ https://www.ncbi.nlm.nih.gov/pubmed/28806103 http://dx.doi.org/10.1080/15548627.2017.1339004 |