Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic

Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for cl...

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Detalles Bibliográficos
Autores principales: Nicol, Dianne, Eckstein, Lisa, Morrison, Michael, Sherkow, Jacob S., Otlowski, Margaret, Whitton, Tess, Bubela, Tania, Burdon, Kathryn P., Chalmers, Don, Chan, Sarah, Charlesworth, Jac, Critchley, Christine, Crossley, Merlin, de Lacey, Sheryl, Dickinson, Joanne L., Hewitt, Alex W., Kamens, Joanne, Kato, Kazuto, Kleiderman, Erika, Kodama, Satoshi, Liddicoat, John, Mackey, David A., Newson, Ainsley J., Nielsen, Jane, Wagner, Jennifer K., McWhirter, Rebekah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612325/
https://www.ncbi.nlm.nih.gov/pubmed/28946923
http://dx.doi.org/10.1186/s13073-017-0475-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612325/
https://www.ncbi.nlm.nih.gov/pubmed/28946923
http://dx.doi.org/10.1186/s13073-017-0475-4

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