Cargando…
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic
Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for cl...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612325/ https://www.ncbi.nlm.nih.gov/pubmed/28946923 http://dx.doi.org/10.1186/s13073-017-0475-4 |
| _version_ | 1783266085561171968 |
|---|---|
| author | Nicol, Dianne Eckstein, Lisa Morrison, Michael Sherkow, Jacob S. Otlowski, Margaret Whitton, Tess Bubela, Tania Burdon, Kathryn P. Chalmers, Don Chan, Sarah Charlesworth, Jac Critchley, Christine Crossley, Merlin de Lacey, Sheryl Dickinson, Joanne L. Hewitt, Alex W. Kamens, Joanne Kato, Kazuto Kleiderman, Erika Kodama, Satoshi Liddicoat, John Mackey, David A. Newson, Ainsley J. Nielsen, Jane Wagner, Jennifer K. McWhirter, Rebekah E. |
| author_facet | Nicol, Dianne Eckstein, Lisa Morrison, Michael Sherkow, Jacob S. Otlowski, Margaret Whitton, Tess Bubela, Tania Burdon, Kathryn P. Chalmers, Don Chan, Sarah Charlesworth, Jac Critchley, Christine Crossley, Merlin de Lacey, Sheryl Dickinson, Joanne L. Hewitt, Alex W. Kamens, Joanne Kato, Kazuto Kleiderman, Erika Kodama, Satoshi Liddicoat, John Mackey, David A. Newson, Ainsley J. Nielsen, Jane Wagner, Jennifer K. McWhirter, Rebekah E. |
| author_sort | Nicol, Dianne |
| collection | PubMed |
| description | Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy. |
| format | Online Article Text |
| id | pubmed-5612325 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-56123252017-10-11 Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic Nicol, Dianne Eckstein, Lisa Morrison, Michael Sherkow, Jacob S. Otlowski, Margaret Whitton, Tess Bubela, Tania Burdon, Kathryn P. Chalmers, Don Chan, Sarah Charlesworth, Jac Critchley, Christine Crossley, Merlin de Lacey, Sheryl Dickinson, Joanne L. Hewitt, Alex W. Kamens, Joanne Kato, Kazuto Kleiderman, Erika Kodama, Satoshi Liddicoat, John Mackey, David A. Newson, Ainsley J. Nielsen, Jane Wagner, Jennifer K. McWhirter, Rebekah E. Genome Med Comment Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy. BioMed Central 2017-09-25 /pmc/articles/PMC5612325/ /pubmed/28946923 http://dx.doi.org/10.1186/s13073-017-0475-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Comment Nicol, Dianne Eckstein, Lisa Morrison, Michael Sherkow, Jacob S. Otlowski, Margaret Whitton, Tess Bubela, Tania Burdon, Kathryn P. Chalmers, Don Chan, Sarah Charlesworth, Jac Critchley, Christine Crossley, Merlin de Lacey, Sheryl Dickinson, Joanne L. Hewitt, Alex W. Kamens, Joanne Kato, Kazuto Kleiderman, Erika Kodama, Satoshi Liddicoat, John Mackey, David A. Newson, Ainsley J. Nielsen, Jane Wagner, Jennifer K. McWhirter, Rebekah E. Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_full | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_fullStr | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_full_unstemmed | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_short | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_sort | key challenges in bringing crispr-mediated somatic cell therapy into the clinic |
| topic | Comment |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612325/ https://www.ncbi.nlm.nih.gov/pubmed/28946923 http://dx.doi.org/10.1186/s13073-017-0475-4 |
| work_keys_str_mv | AT nicoldianne keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT ecksteinlisa keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT morrisonmichael keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT sherkowjacobs keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT otlowskimargaret keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT whittontess keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT bubelatania keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT burdonkathrynp keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT chalmersdon keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT chansarah keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT charlesworthjac keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT critchleychristine keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT crossleymerlin keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT delaceysheryl keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT dickinsonjoannel keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT hewittalexw keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT kamensjoanne keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT katokazuto keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT kleidermanerika keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT kodamasatoshi keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT liddicoatjohn keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT mackeydavida keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT newsonainsleyj keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT nielsenjane keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT wagnerjenniferk keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic AT mcwhirterrebekahe keychallengesinbringingcrisprmediatedsomaticcelltherapyintotheclinic |