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PPARγ coactivator-1α (PGC-1α) protects neuroblastoma cells against amyloid-beta (Aβ) induced cell death and neuroinflammation via NF-κB pathway

BACKGROUND: Alzheimer’s disease is characterized by the accumulation of amyloid beta (Aβ) and the formation of neurofibrillary tangles. Aβ is the main constituent of senile plaques and is largely involved in neuronal death and neuroinflammation. Peroxisome proliferator-activated receptor gamma coact...

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Detalles Bibliográficos
Autores principales: Zhang, Yuqin, Chen, Changchun, Jiang, Yanliu, Wang, Shupei, Wu, Xiaoyu, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612334/
https://www.ncbi.nlm.nih.gov/pubmed/28946859
http://dx.doi.org/10.1186/s12868-017-0387-7