Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) cells are highly dependent on microenvironment, being the BCR pathway one key player in this crosstalk. Among proteins participating, ZAP-70 enhances response to microenvironmental stimuli. MicroRNA-21 (miR-21) is overexpressed in diverse neoplasias including CLL,...

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Detalles Bibliográficos
Autores principales: Carabia, Júlia, Carpio, Cecilia, Abrisqueta, Pau, Jiménez, Isabel, Purroy, Noelia, Calpe, Eva, Palacio, Carles, Bosch, Francesc, Crespo, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612928/
https://www.ncbi.nlm.nih.gov/pubmed/28947822
http://dx.doi.org/10.1038/s41598-017-12135-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612928/
https://www.ncbi.nlm.nih.gov/pubmed/28947822
http://dx.doi.org/10.1038/s41598-017-12135-7

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