Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade

Doxorubicin (DOX) mediated cardiomyopathy is a major challenge in cancer chemotherapy. Redox-cycling of doxorubicin by flavoenzymes makes the heart more vulnerable to oxidative stress leading to cardiac dysfunction. The present study evaluates the role of neferine, a bisbenzylisoquinoline alkaloid,...

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Detalles Bibliográficos
Autores principales: Priya, Lohanathan Bharathi, Baskaran, Rathinasamy, Huang, Chih-Yang, Padma, Viswanadha Vijaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612945/
https://www.ncbi.nlm.nih.gov/pubmed/28947826
http://dx.doi.org/10.1038/s41598-017-12060-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612945/
https://www.ncbi.nlm.nih.gov/pubmed/28947826
http://dx.doi.org/10.1038/s41598-017-12060-9

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