Fenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1

Glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) analogues are approved for treating type 2 diabetes, but are known to activate GLP-1R signaling globally and constitutively. Active compound N55, previously isolated from fenugreek, enhances the potency of GLP-1 without activating GLP-1R. Here we inv...

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Detalles Bibliográficos
Autores principales: Chou, I-Wen, Cheng, Yu-Hong, Chen, Yet-Ran, Hsieh, Patrick Ching-Ho, King, Klim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613011/
https://www.ncbi.nlm.nih.gov/pubmed/28947828
http://dx.doi.org/10.1038/s41598-017-12290-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613011/
https://www.ncbi.nlm.nih.gov/pubmed/28947828
http://dx.doi.org/10.1038/s41598-017-12290-x

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