Bis-anthracycline WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation

Anthracycline chemotherapeutics, e.g. doxorubicin and daunorubicin, are active against a broad spectrum of cancers. Their cytotoxicity is mainly attributed to DNA intercalation, interference with topoisomerase activity, and induction of double-stranded DNA breaks. Since modification of anthracycline...

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Detalles Bibliográficos
Autores principales: Olbryt, Magdalena, Rusin, Aleksandra, Fokt, Izabela, Habryka, Anna, Tudrej, Patrycja, Student, Sebastian, Sochanik, Aleksander, Zieliński, Rafał, Priebe, Waldemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613070/
https://www.ncbi.nlm.nih.gov/pubmed/28417283
http://dx.doi.org/10.1007/s10637-017-0465-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613070/
https://www.ncbi.nlm.nih.gov/pubmed/28417283
http://dx.doi.org/10.1007/s10637-017-0465-9

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