Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme situated downstream of cyclo-oxygenase-2, promoting the excessive PGE(2) production in inflammation. Dexamethasone is known to suppress mPGES-1 but the mechanisms regulating mPGES-1 expression remain poorly known. MKP-1 is a phos...

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Detalles Bibliográficos
Autores principales: Tuure, Lauri, Hämäläinen, Mari, Whittle, Brendan J., Moilanen, Eeva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613146/
https://www.ncbi.nlm.nih.gov/pubmed/28983247
http://dx.doi.org/10.3389/fphar.2017.00646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613146/
https://www.ncbi.nlm.nih.gov/pubmed/28983247
http://dx.doi.org/10.3389/fphar.2017.00646

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