Biochemical characterization and novel inhibitor identification of Mycobacterium tuberculosis Endonuclease VIII 2 (Rv3297)

Nei2 (Rv3297) is a DNA Base Excision Repair (BER) glycosylase that is essential for survival of Mycobacterium tuberculosis in primates. We show that MtbNei2 is a bifunctional glycosylase that specifically acts on oxidized pyrimidine-containing single-stranded, double-stranded, 5’/3’ fork and bubble...

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Detalles Bibliográficos
Autores principales: Lata, Kiran, Afsar, Mohammad, Ramachandran, Ravishankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613217/
https://www.ncbi.nlm.nih.gov/pubmed/28955788
http://dx.doi.org/10.1016/j.bbrep.2017.07.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613217/
https://www.ncbi.nlm.nih.gov/pubmed/28955788
http://dx.doi.org/10.1016/j.bbrep.2017.07.010

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