Cargando…

Biochemical characterization and novel inhibitor identification of Mycobacterium tuberculosis Endonuclease VIII 2 (Rv3297)

Nei2 (Rv3297) is a DNA Base Excision Repair (BER) glycosylase that is essential for survival of Mycobacterium tuberculosis in primates. We show that MtbNei2 is a bifunctional glycosylase that specifically acts on oxidized pyrimidine-containing single-stranded, double-stranded, 5’/3’ fork and bubble...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lata, Kiran, Afsar, Mohammad, Ramachandran, Ravishankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613217/ https://www.ncbi.nlm.nih.gov/pubmed/28955788 http://dx.doi.org/10.1016/j.bbrep.2017.07.010

Ejemplares similares

Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis
por: Lee, Sanghyun, et al.
Publicado: (2019)

Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv
por: Shrivastava, Tripti, et al.
Publicado: (2007)

PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa
por: Tan, Hao, et al.
Publicado: (2016)

Evaluation of Rv0220, Rv2958c, Rv2994 and Rv3347c of Mycobacterium tuberculosis for serodiagnosis of tuberculosis
por: You, Xiaolong, et al.
Publicado: (2017)

Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis
por: Zhao, Nan, et al.
Publicado: (2015)

Correction: Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis
Publicado: (2015)

Designing of inhibitors against drug tolerant Mycobacterium tuberculosis (H37Rv)
por: Singla, Deepak, et al.
Publicado: (2013)

Thermodynamics of the DNA Repair Process by Endonuclease VIII
por: Kladova, O. A., et al.
Publicado: (2019)

The structure of Rv3717 reveals a novel amidase from Mycobacterium tuberculosis
por: Kumar, Atul, et al.
Publicado: (2013)

Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates
por: Shahi, Fatemeh, et al.
Publicado: (2021)

Biochemical Characterization of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and Inhibition of Its Activity by Pyrazinamide
por: Kim, Hyun, et al.
Publicado: (2014)

Rv2031c of Mycobacterium tuberculosis: a master regulator of Rv2028–Rv2031 (HspX) operon
por: Mushtaq, Khurram, et al.
Publicado: (2015)

Rv1453 is associated with clofazimine resistance in Mycobacterium tuberculosis
por: Zhang, Lei, et al.
Publicado: (2023)

Consistency of standard laboratory strain Mycobacterium tuberculosis H(37)Rv with ethionamide susceptibility testing
por: Lakshmi, R., et al.
Publicado: (2012)

Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis
por: Peterson, Eliza J.R., et al.
Publicado: (2016)

Identification and evaluation of the novel immunodominant antigen Rv2351c from Mycobacterium tuberculosis
por: Wang, Xuezhi, et al.
Publicado: (2017)

Biochemical characterization of PE_PGRS61 family protein of Mycobacterium tuberculosis H(37)Rv reveals the binding ability to fibronectin
por: Monu,, et al.
Publicado: (2016)

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection
por: Kimuda, Simon G., et al.
Publicado: (2017)

Transcription factors Rv0081 and Rv3334 connect the early and the enduring hypoxic response of Mycobacterium tuberculosis
por: Sun, Xian, et al.
Publicado: (2018)

Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis
por: Gomez, Andromeda, et al.
Publicado: (2016)

Enhanced serodiagnostic potential of a fusion molecule consisting of Rv1793, Rv2628 and a truncated Rv2608 of Mycobacterium tuberculosis
por: Sulman, Sadaf, et al.
Publicado: (2021)

Mycobacterium tuberculosis Rv0494 Protein Contributes to Mycobacterial Persistence
por: Ji, Lei, et al.
Publicado: (2023)

Characterization of a Novel Esterase Rv0045c from Mycobacterium tuberculosis
por: Guo, Jiubiao, et al.
Publicado: (2010)

Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis
por: Dang, Guanghui, et al.
Publicado: (2016)

The putative compatible solute-binding protein ProX from Mycobacterium tuberculosis H37Rv: biochemical characterization and crystallographic data
por: Zhao, Jian-Hong, et al.
Publicado: (2018)

Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis
por: Pathak, Deepika, et al.
Publicado: (2016)

Mycobacterium tuberculosis H37Rv: In Silico Drug Targets Identification by Metabolic Pathways Analysis
por: Amir, Asad, et al.
Publicado: (2014)

Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c Proteins Participate in the Suppression of Macrophage Apoptosis
por: Danelishvili, Lia, et al.
Publicado: (2010)

Antigens Rv0310c and Rv1255c are promising novel biomarkers for the diagnosis of Mycobacterium tuberculosis infection
por: Luo, Liulin, et al.
Publicado: (2017)

MiaA (Rv2727c) mediated tRNA isopentenylation of Mycobacterium tuberculosis H37Rv
por: Soman, Smitha, et al.
Publicado: (2022)

Design and characterisation of piperazine-benzofuran integrated dinitrobenzenesulfonamide as Mycobacterium tuberculosis H37Rv strain inhibitors
por: Murthy, Vallabhaneni S., et al.
Publicado: (2021)

Endonuclease IV Is the Major Apurinic/Apyrimidinic Endonuclease in Mycobacterium tuberculosis and Is Important for Protection against Oxidative Damage
por: Puri, Rupangi Verma, et al.
Publicado: (2013)

Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis
por: Bolla, Jani Reddy, et al.
Publicado: (2012)

Circularization of rv0678 for Genotypic Bedaquiline Resistance Testing of Mycobacterium tuberculosis
por: Limberis, Jason D., et al.
Publicado: (2023)

Identification of two Mycobacterium tuberculosis H37Rv ORFs involved in resistance to killing by human macrophages
por: Miller, Barbara H, et al.
Publicado: (2001)

The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases
por: Ramulu, Hemalatha G., et al.
Publicado: (2007)

The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in Macrophages
por: Tiwari, Bhavana Mishra, et al.
Publicado: (2012)

Mutational and Kinetic Analysis of Lesion Recognition by Escherichia coli Endonuclease VIII
por: Kladova, Olga A., et al.
Publicado: (2017)

Distinct Mechanisms of Target Search by Endonuclease VIII-like DNA Glycosylases
por: Diatlova, Evgeniia A., et al.
Publicado: (2022)

TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen Rv3203 against Mycobacterium tuberculosis H37Rv in Experimental Animals
por: Mohammad, Owais, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_lricfmmscaprpkg22c71g08cr8