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Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification

Flavoenzymes are ubiquitous in biological systems and catalyze a diverse range of chemical transformations. The flavoenzyme XiaK from the biosynthetic pathway of the indolosesquiterpene xiamycin A is demonstrated to mediate the in vivo biotransformation of xiamycin A into multiple products, includin...

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Detalles Bibliográficos
Autores principales: Zhang, Qingbo, Li, Huixian, Yu, Lu, Sun, Yu, Zhu, Yiguang, Zhu, Hanning, Zhang, Liping, Li, Shu-Ming, Shen, Yuemao, Tian, Changlin, Li, Ang, Liu, Hung-wen, Zhang, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613243/
https://www.ncbi.nlm.nih.gov/pubmed/28970893
http://dx.doi.org/10.1039/c7sc01182b