Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

Oxidative stress is linked to the etiology of Alzheimer’s disease (AD), the most common cause of dementia in the elderly. Redox active metal ions such as copper catalyze the production of Reactive Oxygen Species (ROS) when bound to the amyloid-β (Aβ) peptide encountered in AD. We propose that this r...

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Detalles Bibliográficos
Autores principales: Cheignon, Clémence, Jones, Megan, Atrián-Blasco, Elena, Kieffer, Isabelle, Faller, Peter, Collin, Fabrice, Hureau, Christelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613283/
https://www.ncbi.nlm.nih.gov/pubmed/28970897
http://dx.doi.org/10.1039/c7sc00809k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613283/
https://www.ncbi.nlm.nih.gov/pubmed/28970897
http://dx.doi.org/10.1039/c7sc00809k

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