Function and conformation analyses of an aspartate substitution of the invariant glycine in the integrin βI domain α1-α1′ helix

We showed that the αLβ2 integrin with the non-functional mutation G150D cannot be induced with Mg/EGTA to express the mAb KIM127 epitope, which reports the leg-extended conformation. We extended the study to the αIIbβ3, an integrin without an αI domain. The equivalent mutation, i.e. G161D, also resu...

Descripción completa

Detalles Bibliográficos
Autores principales: Guan, Siyu, Tan, Suet-Mien, Li, Yan, Torres, Jaume, Alex Law, S.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613341/
https://www.ncbi.nlm.nih.gov/pubmed/28955909
http://dx.doi.org/10.1016/j.bbrep.2016.06.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613341/
https://www.ncbi.nlm.nih.gov/pubmed/28955909
http://dx.doi.org/10.1016/j.bbrep.2016.06.013

Ejemplares similares