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Function and conformation analyses of an aspartate substitution of the invariant glycine in the integrin βI domain α1-α1′ helix
We showed that the αLβ2 integrin with the non-functional mutation G150D cannot be induced with Mg/EGTA to express the mAb KIM127 epitope, which reports the leg-extended conformation. We extended the study to the αIIbβ3, an integrin without an αI domain. The equivalent mutation, i.e. G161D, also resu...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613341/ https://www.ncbi.nlm.nih.gov/pubmed/28955909 http://dx.doi.org/10.1016/j.bbrep.2016.06.013 |