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Vesicle Docking Is a Key Target of Local PI(4,5)P(2) Metabolism in the Secretory Pathway of INS-1 Cells
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) signaling is transient and spatially confined in live cells. How this pattern of signaling regulates transmitter release and hormone secretion has not been addressed. We devised an optogenetic approach to control PI(4,5)P(2) levels in time and spac...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613661/ https://www.ncbi.nlm.nih.gov/pubmed/28793264 http://dx.doi.org/10.1016/j.celrep.2017.07.041 |