Cargando…
Host proteostasis modulates influenza evolution
Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens. RNA viruses typically have high mutation rates, resulting in frequent production of protein variants with compromised biophysical properties...
Autores principales: | Phillips, Angela M, Gonzalez, Luna O, Nekongo, Emmanuel E, Ponomarenko, Anna I, McHugh, Sean M, Butty, Vincent L, Levine, Stuart S, Lin, Yu-Shan, Mirny, Leonid A, Shoulders, Matthew D |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614556/ https://www.ncbi.nlm.nih.gov/pubmed/28949290 http://dx.doi.org/10.7554/eLife.28652 |
Ejemplares similares
-
Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin
por: Phillips, Angela M, et al.
Publicado: (2018) -
The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope
por: Yoon, Jimin, et al.
Publicado: (2022) -
Proteostasis is differentially modulated by inhibition of translation initiation or elongation
por: Clay, Khalyd J, et al.
Publicado: (2023) -
Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones
por: Phillips, Angela M., et al.
Publicado: (2018) -
Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms
por: Solis, Gregory M, et al.
Publicado: (2018)