Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways

Thymoquinone, a natural occurring quinone and the main bioactive component of plant Nigella sativa, undergoes intracellular redox cycling and re-oxidizes NADH to NAD(+). TQ administration (20 mg/kg/bw/day) to the Diet-Induced Obesity (DIO) mice reduced their diabetic phenotype by decreasing fasting...

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Detalles Bibliográficos
Autores principales: Karandrea, Shpetim, Yin, Huquan, Liang, Xiaomei, Slitt, Angela L., Heart, Emma A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614580/
https://www.ncbi.nlm.nih.gov/pubmed/28950020
http://dx.doi.org/10.1371/journal.pone.0185374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614580/
https://www.ncbi.nlm.nih.gov/pubmed/28950020
http://dx.doi.org/10.1371/journal.pone.0185374

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