Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates

Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrP(Sc). This effect has been associated with differences in foldi...

Descripción completa

Detalles Bibliográficos
Autores principales: Groveman, Bradley R., Raymond, Gregory J., Campbell, Katrina J., Race, Brent, Raymond, Lynne D., Hughson, Andrew G., Orrú, Christina D., Kraus, Allison, Phillips, Katie, Caughey, Byron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614645/
https://www.ncbi.nlm.nih.gov/pubmed/28910420
http://dx.doi.org/10.1371/journal.ppat.1006623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614645/
https://www.ncbi.nlm.nih.gov/pubmed/28910420
http://dx.doi.org/10.1371/journal.ppat.1006623

Ejemplares similares