Cargando…
Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates
Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrP(Sc). This effect has been associated with differences in foldi...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614645/ https://www.ncbi.nlm.nih.gov/pubmed/28910420 http://dx.doi.org/10.1371/journal.ppat.1006623 |