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Stochastic principles governing alternative splicing of RNA

The dominance of the major transcript isoform relative to other isoforms from the same gene generated by alternative splicing (AS) is essential to the maintenance of normal cellular physiology. However, the underlying principles that determine such dominance remain unknown. Here, we analyzed the phy...

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Detalles Bibliográficos
Autores principales: Hu, Jianfei, Boritz, Eli, Wylie, William, Douek, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614656/
https://www.ncbi.nlm.nih.gov/pubmed/28910283
http://dx.doi.org/10.1371/journal.pcbi.1005761