Nitric oxide inhibits ATPase activity and induces resistance to topoisomerase II-poisons in human MCF-7 breast tumor cells

BACKGROUND: Topoisomerase poisons are important drugs for the management of human malignancies. Nitric oxide ((•)NO), a physiological signaling molecule, induces nitrosylation (or nitrosation) of many cellular proteins containing cysteine thiol groups, altering their cellular functions. Topoisomeras...

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Detalles Bibliográficos
Autores principales: Sinha, Birandra K., Kumar, Ashutosh, Mason, Ronald P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614683/
https://www.ncbi.nlm.nih.gov/pubmed/28955753
http://dx.doi.org/10.1016/j.bbrep.2017.04.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614683/
https://www.ncbi.nlm.nih.gov/pubmed/28955753
http://dx.doi.org/10.1016/j.bbrep.2017.04.011

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