rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model

Recombinant adeno-associated virus (rAAV) vectors are clinically adapted vectors to durably treat human osteoarthritis (OA). Controlled delivery of rAAV vectors via polymeric micelles was reported to enhance the temporal and spatial presentation of the vectors into their targets. Here, we tested the...

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Detalles Bibliográficos
Autores principales: Rey-Rico, Ana, Venkatesan, Jagadeesh K, Schmitt, Gertrud, Concheiro, Angel, Madry, Henning, Alvarez-Lorenzo, Carmen, Cucchiarini, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614797/
https://www.ncbi.nlm.nih.gov/pubmed/29033566
http://dx.doi.org/10.2147/IJN.S144579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614797/
https://www.ncbi.nlm.nih.gov/pubmed/29033566
http://dx.doi.org/10.2147/IJN.S144579

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