MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity

MicroRNAs (miRNAs) that regulate the cytochrome P-450 isoforms involved in acetaminophen (APAP) toxicity were examined in HepaRG cells treated with APAP (20 mM). In-vitro studies found that APAP protein adducts were increased at 1 h, followed by ALT increases at 12 and 24 h. CYP1A2, CYP3A4 and CYP2E...

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Detalles Bibliográficos
Autores principales: Gill, Pritmohinder, Bhattacharyya, Sudeepa, McCullough, Sandra, Letzig, Lynda, Mishra, Prasun J., Luo, Chunqiao, Dweep, Harsh, James, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614957/
https://www.ncbi.nlm.nih.gov/pubmed/28951593
http://dx.doi.org/10.1038/s41598-017-11811-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614957/
https://www.ncbi.nlm.nih.gov/pubmed/28951593
http://dx.doi.org/10.1038/s41598-017-11811-y

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