Xanthates As Useful Probes for Testing the Active Sites of Cytochromes P450 4A11 and 2E1

Xanthates (alkyl or aryl derivatives of dithiocarbonic acid) have been shown to be selective mechanism-based inactivators of cytochromes P450 2B1/2B6 and 2E1 due to covalent binding of a reactive intermediate to apoprotein after double hydrogen abstraction at α-carbon atom, suggesting interaction of...

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Detalles Bibliográficos
Autores principales: Stoyanova, Tsveta, Lessigiarska, Iglika, Mikov, Momir, Pajeva, Ilza, Yanev, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614966/
https://www.ncbi.nlm.nih.gov/pubmed/29018344
http://dx.doi.org/10.3389/fphar.2017.00672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614966/
https://www.ncbi.nlm.nih.gov/pubmed/29018344
http://dx.doi.org/10.3389/fphar.2017.00672

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