Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons

Global cerebral ischemia results in oxygen and glucose deprivation (OGD) and consequent delayed cell death of vulnerable neurons, with hippocampal CA1 neurons more vulnerable than cortical neurons. Most AMPA receptors (AMPARs) are heteromeric complexes of subunits GluA1/GluA2 or GluA2/GluA3, and the...

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Detalles Bibliográficos
Autores principales: Koszegi, Zsombor, Fiuza, Maria, Hanley, Jonathan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614987/
https://www.ncbi.nlm.nih.gov/pubmed/28951554
http://dx.doi.org/10.1038/s41598-017-12534-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614987/
https://www.ncbi.nlm.nih.gov/pubmed/28951554
http://dx.doi.org/10.1038/s41598-017-12534-w

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