Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products

O-GlcNAc transferase (OGT) plays an important role in regulating numerous cellular processes through reversible post-translational modification of nuclear and cytoplasmic proteins. However, the function of O-GlcNAcylation is still not well understood. Cell permeable OGT inhibitors are needed to mani...

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Detalles Bibliográficos
Autores principales: Liu, Yubo, Ren, Yang, Cao, Yu, Huang, Huang, Wu, Qiong, Li, Wenli, Wu, Sijin, Zhang, Jianing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615061/
https://www.ncbi.nlm.nih.gov/pubmed/28951553
http://dx.doi.org/10.1038/s41598-017-12522-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615061/
https://www.ncbi.nlm.nih.gov/pubmed/28951553
http://dx.doi.org/10.1038/s41598-017-12522-0

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