Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels

Recurrent high-frequency epileptic seizures cause progressive hippocampal sclerosis, which is associated with caspase-3 activation and NMDA receptor-dependent excitotoxicity. However, the identity of caspase-3 substrates that contribute to seizure-induced hippocampal atrophy remains largely unknown....

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Detalles Bibliográficos
Autores principales: Baculis, Brian C., Weiss, Amanda C., Pang, Weilun, Jeong, Han Gil, Lee, Jun Hee, Liu, Dai-Chi, Tsai, Nien-Pei, Chung, Hee Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615076/
https://www.ncbi.nlm.nih.gov/pubmed/28951616
http://dx.doi.org/10.1038/s41598-017-12508-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615076/
https://www.ncbi.nlm.nih.gov/pubmed/28951616
http://dx.doi.org/10.1038/s41598-017-12508-y

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