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Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels

Recurrent high-frequency epileptic seizures cause progressive hippocampal sclerosis, which is associated with caspase-3 activation and NMDA receptor-dependent excitotoxicity. However, the identity of caspase-3 substrates that contribute to seizure-induced hippocampal atrophy remains largely unknown....

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Detalles Bibliográficos
Autores principales:	Baculis, Brian C., Weiss, Amanda C., Pang, Weilun, Jeong, Han Gil, Lee, Jun Hee, Liu, Dai-Chi, Tsai, Nien-Pei, Chung, Hee Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615076/ https://www.ncbi.nlm.nih.gov/pubmed/28951616 http://dx.doi.org/10.1038/s41598-017-12508-y

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