Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations

Multi-wavelength fluorescence spectroscopy was evaluated in this work as tool for real-time monitoring of antibody aggregation in CHO fed-batch cultivations via partial least square (PLS) modeling. Therefore, we used the extrinsic fluorescence dyes 1-anilinonaphthalene-8-sulfonate (ANS), 4,4′-bis-1-...

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Detalles Bibliográficos
Autores principales: Schwab, Karen, Hesse, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615311/
https://www.ncbi.nlm.nih.gov/pubmed/28952544
http://dx.doi.org/10.3390/bioengineering4030065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615311/
https://www.ncbi.nlm.nih.gov/pubmed/28952544
http://dx.doi.org/10.3390/bioengineering4030065

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