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HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus
BACKGROUND: Systemic lupus erythematosus (SLE) is associated with B cell hyperactivity, and lupus nephritis (LN), in particular, is promoted by the production of autoantibodies and immune complex deposition. Bruton’s tyrosine kinase (BTK) plays critical roles in B cell receptor-related and Fc recept...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615432/ https://www.ncbi.nlm.nih.gov/pubmed/28950886 http://dx.doi.org/10.1186/s13075-017-1402-1 |