Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

BACKGROUND: α7 nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system and are reported to have neuroprotective properties. α7 nAChRs are expressed on astrocytes, which are key regulators of neuroinflammation and oxidative stress in several neurodegene...

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Detalles Bibliográficos
Autores principales: Patel, Hiral, McIntire, Jessica, Ryan, Sarah, Dunah, Anthone, Loring, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615458/
https://www.ncbi.nlm.nih.gov/pubmed/28950908
http://dx.doi.org/10.1186/s12974-017-0967-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615458/
https://www.ncbi.nlm.nih.gov/pubmed/28950908
http://dx.doi.org/10.1186/s12974-017-0967-6

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