Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive fat deposits in hepatocytes without excessive alcohol intake. NAFLD is influenced by genetic factors, and the heritability has been estimated at 0.35 to 0.6 by twin studies. We explored rare variants in kn...

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Detalles Bibliográficos
Autores principales: Boonvisut, Supichaya, Yoshida, Ken, Nakayama, Kazuhiro, Watanabe, Kazuhisa, Miyashita, Hiroshi, Iwamoto, Sadahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615465/
https://www.ncbi.nlm.nih.gov/pubmed/28950858
http://dx.doi.org/10.1186/s12944-017-0570-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615465/
https://www.ncbi.nlm.nih.gov/pubmed/28950858
http://dx.doi.org/10.1186/s12944-017-0570-y

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