Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats

Tetrabromobisphenol A (TBBPA), a nongenotoxic flame retardant, causes uterine tumors in female rats. A proposed mode of action (MoA) for these tumors involves an increase in the bioavailability of estradiol as a result of TBBPA inhibiting estrogen sulfotransferases (ES), the enzymes responsible for...

Descripción completa

Detalles Bibliográficos
Autores principales: Borghoff, S.J., Wikoff, D., Harvey, S., Haws, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615791/
https://www.ncbi.nlm.nih.gov/pubmed/28959539
http://dx.doi.org/10.1016/j.toxrep.2016.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615791/
https://www.ncbi.nlm.nih.gov/pubmed/28959539
http://dx.doi.org/10.1016/j.toxrep.2016.01.007

Ejemplares similares